Custom Synthesis

LACTEL can provide developmental input and custom synthesis

If additional product optimization is required, we can provide developmental input and custom synthesis. A large percentage of our polymer business at DURECT is devoted to the development of polymers with customized characteristics.

For example, we have worked closely with clients to:

Subtle changes in molecular architecture can have a profound effect on degradation and drug release rates. For example, altering the polymer end groups can affect water uptake and degradation rate. Typical examples are shown below. Our scientists can help you determine the characteristics necessary for your application through developmental input and custom synthesis. Please contact Technical Support to discuss your needs.

Initiator-Polymer End Group Effects


Initiator End Groups Effects
Monofunctional alchohol Ester and Hydroxyl Slightly hydrophilic
Diol Hydroxyl and Hydroxyl More hydrophilic
Water or α-hydroxyl acid Carboxylic acid and Hydroxyl More hydrophilic; increase water uptake and degradation rate
Polyethylene glycol (PEG) PEG and Hydroxyl Most hydrophilic

Order Polymers

We offer a variety of polymers and sample kits in stock for prompt delivery.

Technical Data

Data describing characteristics of lactide, glycolide and ε-caprolactone polymers to assist you in selecting the optimal polymer for your program.

Safety Data Sheets


The following Safety Data Sheets are saved in a format that can be viewed and printed from Acrobat Reader.